RECENT PUBLICATIONS
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
Lang VY, Fatehi M, Light PE.Pharmacogenet Genomics. 2011 Dec 29. [Epub ahead of print]
The ATP-Sensitive K+ Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity.
Fatehi M, Raja M, Carter C, Soliman D, Holt A, Light PE.
Diabetes. 2012 Jan;61(1):241-9.
Myocardial ATGL Over-expression Decreases the Reliance on Fatty Acid Oxidation and Protects Against Pressure Overload-Induced Cardiac Dysfunction.
Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JR.
Mol Cell Biol. 2011 Dec 12. [Epub ahead of print]
Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.
Kruit JK, Wijesekara N, Fox JE, Dai XQ, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Bhattacharjee A, Johnson JD, Light PE, Marsh BJ, Macdonald PE, Verchere CB, Hayden MR.
Diabetes. 2011 Dec;60(12):3186-96. Epub 2011 Oct 12.
The molecular genetics of sulfonylurea receptors in the pathogenesis and treatment of insulin secretory disorders and type 2 diabetes.
Lang V, Youssef N, Light PE.
Curr Diab Rep. 2011 Dec;11(6):543-51.
Variations in tissue selectivity amongst insulin secretagogues: a systematic review.
Abdelmoneim AS, Hasenbank SE, Seubert JM, Brocks DR, Light PE, Simpson SH.
Diabetes Obes Metab. 2012 Feb;14(2):130-8.
Sarcolemmal KATP channel modulators and cardiac arrhythmias.
Baczkó I, Husti Z, Lang V, Leprán I, Light PE.
Curr Med Chem. 2011;18(24):3640-61.
Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction.
Polewicz D, Cadete VJ, Doroszko A, Hunter BE, Sawicka J, Szczesna-Cordary D, Light PE, Sawicki G.
J Cell Mol Med. 2010 May 26.
Inhibition of beta-cell sodium-calcium exchange enhances glucose-dependent elevations in cytoplasmic calcium and insulin secretion.
Hamming KS, Soliman D, Webster NJ, Searle GJ, Matemisz LC, Liknes DA, Dai XQ, Pulinilkunnil T, Riedel MJ, Dyck JR, Macdonald PE, Light PE.
Diabetes. 2010 Jul;59(7):1686-93. Epub 2010 Apr 22.
Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance.
Koonen DP, Sung MM, Kao CK, Dolinsky VW, Koves TR, Ilkayeva O, Jacobs RL, Vance DE, Light PE, Muoio DM, Febbraio M, Dyck JR.
Diabetes. 2010 Jun;59(6):1366-75. Epub 2010 Mar 18.
Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased myocardial glycogen.
Folmes KD, Chan AY, Koonen DP, Pulinilkunnil TC, Baczkó I, Hunter BE, Thorn S, Allard MF, Roberts R, Gollob MH, Light PE, Dyck JR.
Circ Cardiovasc Genet. 2009 Oct;2(5):457-66. Epub 2009 Jul 15.
Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel.
Hamming KS, Soliman D, Matemisz LC, Niazi O, Lang Y, Gloyn AL, Light PE.
Diabetes. 2009 Oct;58(10):2419-24. Epub 2009 Jul 8.
Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner.
Soliman D, Hamming KS, Matemisz LC, Light PE.
J Mol Cell Cardiol. 2009 Nov;47(5):595-602. Epub 2009 May 28.
Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.
Dolinsky VW, Chan AY, Robillard Frayne I, Light PE, Des Rosiers C, Dyck JR.
Circulation. 2009 Mar 31;119(12):1643-52. Epub 2009 Mar 16.
Diastolic calcium is elevated in metabolic recovery of cardiomyocytes expressing elevated levels of the Na+/H+ exchanger.
Baczkó I, Mraiche F, Light PE, Fliegel L.
Can J Physiol Pharmacol. 2008 Dec;86(12):850-9.
The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.
Chee MJ, Mörl K, Lindner D, Merten N, Zamponi GW, Light PE, Beck-Sickinger AG, Colmers WF.
J Biol Chem. 2008 Nov 28;283(48):33337-46. Epub 2008 Sep 23. Erratum in: J Biol Chem. 2009 Feb 6;284(6):4040.
Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As.
Hamming KS, Riedel MJ, Soliman D, Matemisz LC, Webster NJ, Searle GJ, MacDonald PE, Light PE.
Mol Endocrinol. 2008 Oct;22(10):2293-306. Epub 2008 Jul 17.
Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt.
Chan AY, Dolinsky VW, Soltys CL, Viollet B, Baksh S, Light PE, Dyck JR.
J Biol Chem. 2008 Aug 29;283(35):24194-201. Epub 2008 Jun 18.
Hypothalamic protein kinase C regulates glucose production.
Ross R, Wang PY, Chari M, Lam CK, Caspi L, Ono H, Muse ED, Li X, Gutierrez-Juarez R, Light PE, Schwartz GJ, Rossetti L, Lam TK.
Diabetes. 2008 Aug;57(8):2061-5. Epub 2008 May 28.
Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production.
Wang PY, Caspi L, Lam CK, Chari M, Li X, Light PE, Gutierrez-Juarez R, Ang M, Schwartz GJ, Lam TK.
Nature. 2008 Apr 24;452(7190):1012-6. Epub 2008 Apr 9.
Elevation in intracellular long-chain acyl-coenzyme A esters lead to reduced beta-cell excitability via activation of adenosine 5'-triphosphate-sensitive potassium channels.
Webster NJ, Searle GJ, Lam PP, Huang YC, Riedel MJ, Harb G, Gaisano HY, Holt A, Light PE.
Endocrinology. 2008 Jul;149(7):3679-87. Epub 2008 Mar 27.
Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte.
León H, Baczkó I, Sawicki G, Light PE, Schulz R.
Br J Pharmacol. 2008 Feb;153(4):676-83. Epub 2007 Dec 10.
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility.
Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED.
Circulation. 2007 Jul 17;116(3):238-48. Epub 2007 Jul 2.